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Updated: Aug 8, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
[Coexistence of chronic lymphoid leukemia and Hodgkin's disease. Immunohistochemical study]
M J Pérez del Río1, M F Fresno, A Ramírez
1Servicio de Anatomía Patológica, Hospital Ntra, Universidad de Oviedo.
Insights
This study details a rare coexistence of chronic lymphocytic leukemia (CLL) and Hodgkin
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Co-occurrence of distinct lymphoid malignancies is exceptionally rare.
- Chronic lymphocytic leukemia (CLL) and Hodgkin's disease (HD) are distinct B-cell neoplasms.
- Simultaneous presentation in the same lymph node presents diagnostic and therapeutic challenges.
Abstract:
We report a new case of coincidence of chronic lymphocytic leukemia (CLL) and mixed cellularity Hodgkin's disease (HD) in the same lymph node. These findings were corroborated by immunohistochemical study showing Reed-Sternberg (RS) cells, with typical immunophenotype in an inflammatory background, closely related to a small neoplastic lymphoid cell population. This is an uncommon feature, and, to our knowledge, this is the first case published in the Spanish literature.
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