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Naive and memory T cell infiltrates in chronic hepatitis C: phenotypic changes with interferon treatment

K Imada1, Y Fukuda, Y Koyama

  • 1Second Department of Internal Medicine, Nagoya University School of Medicine, Showa-ku, Japan.

Clinical and Experimental Immunology
|July 1, 1997
PubMed

Insights

Chronic hepatitis C involves CD8+ memory T cells in liver injury. Interferon treatment reduces these cells, correlating with decreased liver inflammation in responders.

Area of Science:

  • Immunology
  • Hepatology
  • Virology

Background:

  • Chronic hepatitis C is an inflammatory liver disease.
  • Infiltrating lymphocytes play a role in liver damage.
  • Interferon (IFN) is a treatment for hepatitis C.

Purpose of the Study:

  • To characterize lymphocyte phenotypes in the liver during chronic hepatitis C.
  • To investigate changes in lymphocyte populations with IFN treatment.
  • To correlate lymphocyte subsets with disease severity and treatment response.

Main Methods:

  • Immunohistochemistry (avidin-biotin-peroxidase) was used.
  • Liver specimens from 22 IFN-treated patients were analyzed.
  • Lymphocyte subsets (CD8+, CD4+, CD20+, CD45RO+, CD45RA+) were quantified.

Main Results:

  • CD8+ memory (CD45RO+) T cells were predominant in inflammatory areas.
  • IFN treatment decreased CD45RO+ lobular infiltrates in complete responders.
  • CD45RO+ cell counts correlated with alanine aminotransferase levels, histologic grade, and CD8+ cell counts.

Conclusions:

  • CD8+ memory T cells are implicated in hepatocyte injury in chronic hepatitis C.
  • Reduced CD8+ memory T cells correlate with improved liver inflammation following IFN therapy.

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