Cytologic diagnosis of Ki-1 lymphoma in pleural and peritoneal effusions: a case report

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I T Burja1, S K Thompson, E J Brown

  • 1Cytopathology Section, Veterans Administration Medical Center, Johnson City, Tennessee, USA.

Diagnostic Cytopathology
|August 1, 1997
PubMed

Insights

This report details a rare Ki-1-positive large-cell anaplastic lymphoma case. Diagnosis was confirmed using cytologic examination of body fluids, marking a first for this lymphoma type.

Area of Science:

  • Oncology
  • Hematology
  • Cytopathology

Background:

  • Anaplastic large-cell lymphoma (ALCL) is a distinct type of non-Hodgkin lymphoma.
  • Ki-1 antigen (CD30) is a key marker for diagnosing certain lymphomas.
  • Diagnosis often relies on tissue biopsies, but fluid cytology can be crucial in specific clinical scenarios.

Observation:

  • An 87-year-old male presented with findings suggestive of malignancy.
  • Cytologic examination of pleural and peritoneal fluids revealed large neoplastic cells.
  • Cells exhibited characteristic nuclear features, including multinucleation and wreath-like arrangements.

Findings:

  • Immunohistochemical analysis confirmed the expression of Ki-1 antigen (CD30) and epithelial membrane antigen (EMA) on tumor cells.
  • The cytomorphologic and immunophenotypic findings were consistent with Ki-1-positive large-cell anaplastic lymphoma.
  • This represents the initial diagnosis of Ki-1 lymphoma based on cytologic analysis of body fluids.

Implications:

  • Cytologic examination of pleural and peritoneal fluids can be a valuable tool for the early diagnosis of Ki-1 lymphoma.
  • This case highlights the utility of cytopathology in identifying rare hematologic malignancies.
  • Early diagnosis via fluid analysis may facilitate prompt treatment initiation and improve patient outcomes.

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