Immunohistochemical expression of IL-10 in mycosis fungoides
Experimental Dermatology
|August 1, 1997
Insights
Interleukin-10 (IL-10) is present in mycosis fungoides (MF) skin lesions and T-cells. This cytokine
Area of Science:
- Immunology
- Dermatology
- Oncology
Background:
- Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma.
- The role of cytokines in MF pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the in situ immunoreactivity of interleukin-10 (IL-10) in mycosis fungoides.
- To determine the presence and location of IL-10 expression in MF skin biopsies and T-cell lines.
Main Methods:
- Immunohistochemistry was used to detect IL-10 expression.
- Analysis was performed on skin biopsies (n=8) and T-cell lines (n=2) from MF patients.
Main Results:
- IL-10 positivity was observed in dermal cell infiltrates within MF skin biopsies.
- IL-10 expression was also detected in T-cell lines derived from MF patients.
- Dermal IL-10 reactivity in active MF lesions suggests a potential role in disease progression.
Conclusions:
- The findings indicate that IL-10 is expressed in the cellular infiltrates of mycosis fungoides.
- IL-10 may play a role in the progression of mycosis fungoides.
Abstract:
Immunoreactivity of the cytokine IL-10 has been investigated in situ in mycosis fungoides (MF). Expression of IL-10 was detected using immunohistochemistry in skin biopsies (n = 8) and T-cell lines (n = 2) from mycosis fungoides patients. IL-10 positivity was seen in the dermal cell infiltrates and in T-cell lines in mycosis fungoides. The dermal IL-10 reaction in a skin biopsy from an active lesion in MF indicates the possibility for disease progression.
