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Hairy cell leukemia variant with t(2;8)(p12;q24) abnormality

K F Wong1, Y L Kwong, P K Hui

  • 1Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

Cancer Genetics and Cytogenetics
|October 23, 1997
PubMed

Insights

Hairy cell leukemia variant, a rare B-cell disorder, typically presents with enlarged spleen and high white blood cell counts. This study details a unique case with a specific chromosomal translocation but no c-MYC rearrangement.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Hairy cell leukemia variant (HCL-V) is a rare chronic B-cell lymphoproliferative disorder.
  • Clinical features include splenomegaly and marked leukocytosis.
  • Cytologic distinction from classical hairy cell leukemia involves nucleolar morphology.

Observation:

  • This report describes a patient diagnosed with hairy cell leukemia variant.
  • The patient exhibited a specific chromosomal abnormality: t(2;8)(p12;q34).
  • Notably, the c-MYC oncogene rearrangement was absent in this case.

Findings:

  • Cytogenetic analysis revealed a t(2;8)(p12;q34) translocation in the hairy cell leukemia variant patient.
  • Absence of c-MYC oncogene rearrangement was confirmed, contrasting with some previous reports.
  • This finding contributes to the limited cytogenetic data available for HCL-V.

Implications:

  • The study expands the understanding of the genetic landscape of hairy cell leukemia variant.
  • It highlights the heterogeneity of chromosomal abnormalities in HCL-V.
  • Further research into the molecular mechanisms underlying HCL-V with different cytogenetic profiles is warranted.

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