Related Experiment Video
Updated: Aug 17, 2026
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
Lymphoplasmacyte-rich meningioma: a case report with histological and immunohistochemical studies
M Mizushima1, Y Tanaka, S Kawakami
1Division of Neurosurgery, Faculty of Medicine, Tottori University, Yonago, Japan.
Insights
A rare lymphoplasmacyte-rich meningioma in a 64-year-old woman mimicked ordinary meningioma. Immunohistochemistry revealed the lymphocytic infiltrate was likely a host immune response, not a neoplastic process.
Area of Science:
- Neuropathology
- Immunohistochemistry
- Neoplastic Pathology
Background:
- Meningiomas are common primary brain tumors, typically benign and slow-growing.
- Lymphoplasmacyte-rich meningiomas represent a rare variant with distinct histological features.
- Distinguishing neoplastic from reactive cellular components is crucial for accurate diagnosis.
Observation:
- A 64-year-old female patient presented with a tumor exhibiting typical meningioma radiographic and macroscopic appearance.
- Immunohistochemical staining of meningothelial cell components was positive for epithelial membrane antigen.
- Analysis of lymphocyte surface markers (L26, UCHL-1) was performed on the tumor infiltrate.
Findings:
- The meningothelial cells confirmed the diagnosis of meningioma.
- The lymphoplasmacytic proliferation within the tumor was negative for neoplastic markers.
- Immunohistochemical results strongly suggested the infiltrate represented a host immune response rather than a neoplastic proliferation.
Implications:
- This case highlights the importance of comprehensive immunohistochemical analysis in diagnosing rare meningioma variants.
- Understanding the nature of the lymphoplasmacytic infiltrate can refine diagnostic criteria for lymphoplasmacyte-rich meningiomas.
- Differentiating reactive immune cells from neoplastic lymphocytes is critical for appropriate patient management and prognosis.
Abstract:
This report concerns a 64-year-old woman with a lymphoplasmacyte-rich meningioma. Radiographically and macroscopically, the tumor had the appearance of an ordinary meningioma. Components of the meningothelial cells were positively immunostained for epithelial membrane antigen. The results of immunohistochemical assays with the antibodies to surface markers of lymphocytes L26 and UCHL-1 indicated that the lymphoplasmacellular proliferation was not neoplastic but probably represented an immune reaction of the host.
