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Lymphoepithelial cyst of the pancreas
R Gafă1, E Grandi, L Cavazzini
1Dipartimento di Medicina, Sperimentale e Diagnostica-Sezione di Anatomia Istologia e Citologia Patologica, Università di Ferrara, Italy.
Insights
A rare lymphoepithelial cyst of the pancreas, characterized by squamous epithelium and lymphoid tissue, is presented. This finding aids in distinguishing it from other pancreatic cystic lesions.
Area of Science:
- Gastroenterology
- Pathology
- Surgical Oncology
Background:
- Pancreatic cystic lesions represent a diverse group of pathologies.
- Accurate diagnosis is crucial for appropriate patient management and treatment strategies.
Observation:
- A rare case of pancreatic lymphoepithelial cyst was identified.
- Microscopic examination revealed keratinous cyst content, squamous epithelial lining, and surrounding lymphoid tissue.
Findings:
- Immunohistochemistry confirmed CD20 and CD3 positivity in the lymphoid tissue.
- Uniform cytokeratin positivity was observed in the squamous epithelium.
- The histogenesis of these cysts remains unclear.
Implications:
- Recognition of this rare entity is vital for differential diagnosis among pancreatic cystic lesions.
- Understanding the unique histological features aids pathologists and clinicians.
- Further research into the origin of these cysts may elucidate their pathogenesis.
Abstract:
A rare case of lymphoepithelial cyst of the pancreas is reported. Microscopically the cyst content consisted of keratinous material and the walls were lined by mature squamous epithelium surrounded by dense lymphoid tissue. Immunohistochemistry showed diffuse reactivity for CD20 and CD3 in the lymphoid tissue and uniform positivity for cytokeratins in the squamous epithelium. Although the histogenesis of lymphoepithelial cysts of the pancreas is not understood, awareness of this lesion is helpful in differentiating it from other pancreatic cystic lesions.