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Published on: February 2, 2014
[Intravascular malignant lymphomatosis]
1Aalborg Sygehus, patologisk institut.
Insights
Intravascular malignant lymphomatosis (IML) is a rare lymphoma. Early diagnosis and chemotherapy offer potential for remission in this aggressive condition.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Intravascular malignant lymphomatosis (IML) is a rare extranodal non-Hodgkin lymphoma.
- Characterized by malignant lymphoid cell proliferation within small blood vessel lumens.
Observation:
- A case of IML presented with non-specific pulmonary symptoms, weight loss, and fever.
- Cardiac, cerebral, and skin lesions developed subsequently.
- The patient died within six months, with diagnosis confirmed at autopsy.
Findings:
- IML diagnosis was established post-mortem.
- The condition presented with a complex and evolving set of symptoms mimicking various organ ischemia.
Implications:
- Standard chemotherapy for high-grade lymphomas may achieve remission and long-term survival.
- IML should be considered in the differential diagnosis of unexplained ischemic symptoms affecting multiple organs.
Abstract:
Intravascular malignant lymphomatosis (IML) is a rare form of extranodal non-Hodgkin lymphoma characterized by proliferation of malignant lymphoid cells within the lumen of small blood vessels. We describe a case of IML presenting with non-specific pulmonary symptoms, weight loss, intermittent fever and a confusing collection of laboratory findings. Later on the patient developed cardiac symptoms, and finally diffuse cerebral symptoms and skin lesions. His condition deteriorated and he died within six months. The diagnosis of IML was made at autopsy. Complete remission and long-term disease-free survival may be obtained with standard chemotherapy directed at high-grade lymphomas. It is important to remember IML in the differential diagnosis of patients with confusing and changing ischaemic symptoms and signs from several organs.
