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Comparison of patient reactions and diagnostic quality for hysterosalpingography using ionic and nonionic contrast

M Y Chen1, R J Zagoria, J A Fayez

  • 1Department of Radiology, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1088, USA.

Academic Radiology
|February 1, 1995
PubMed

Insights

Nonionic iohexol contrast media resulted in fewer adverse reactions, particularly abdominal pain, compared to ionic contrast media (diatrizoate meglumine combined with iodipamide meglumine) during hysterosalpingography (HSG). Image quality remained excellent for both.

Area of Science:

  • Radiology
  • Gynecology
  • Medical Imaging

Background:

  • Hysterosalpingography (HSG) is a key diagnostic procedure in gynecology.
  • Contrast media selection impacts patient experience and diagnostic accuracy in HSG.

Purpose of the Study:

  • To compare adverse reactions and image quality between ionic (DM + IM) and nonionic (iohexol) contrast media in HSG.
  • To evaluate the safety and efficacy of different contrast agents for HSG.

Main Methods:

  • A randomized study involving 95 patients undergoing HSG.
  • Patients received either ionic (diatrizoate meglumine + iodipamide meglumine) or nonionic (iohexol) contrast media.
  • Adverse reactions and pain severity were self-reported; image quality was assessed by radiologists.

Main Results:

  • Lower prevalence of immediate and 24-hr adverse reactions, including moderate/severe abdominal pain, with iohexol compared to DM + IM.
  • Excellent visualization of the uterine cavity and ampullary rugae achieved with both contrast media (87-92%).

Conclusions:

  • Both iohexol and DM + IM are effective contrast media for HSG.
  • Iohexol may offer a superior safety profile by reducing the incidence and severity of post-procedural abdominal pain.
Abstract

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