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Chronic lymphocytic leukemia presenting as jaundice
1CIO Research Lab, Safdarjang Hospital, New Delhi.
Insights
Rarely, blood cancers like chronic lymphocytic leukemia (CLL) can cause jaundice. This case highlights paraneoplastic jaundice as an unusual presentation of CLL, impacting liver function.
Area of Science:
- Hematology
- Oncology
- Gastroenterology
Background:
- Hematological and lymphoid malignancies typically manifest within the affected tissues.
- Extranodal presentations of these cancers are uncommon, posing diagnostic challenges.
Observation:
- A patient with chronic lymphocytic leukemia (CLL) presented with jaundice and widespread lymphadenopathy.
- Liver function tests indicated hepatitis, and liver biopsy revealed mild cholestasis.
Findings:
- The clinical presentation and biopsy results suggest paraneoplastic jaundice.
- This indicates an indirect effect of the CLL on liver function.
Implications:
- This case expands the understanding of potential extranodal manifestations of CLL.
- Recognizing paraneoplastic jaundice is crucial for timely diagnosis and management of CLL.
Abstract:
Hematological and lymphoid malignancies rarely present with manifestations outside these tissues. We report a patient with chronic lymphocytic leukemia (CLL) presenting with jaundice and generalized lymphadenopathy. The liver profile was suggestive of hepatitis; biopsy showed mild cholestasis. The findings suggest paraneoplastic jaundice with CLL.