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Primary large cell lymphoma presenting as hilar mass and obstructive jaundice

M Al-Fadda1, B M Fashir

  • 1Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

The American Journal of Gastroenterology
|February 19, 1998
PubMed

Insights

A rare case of large-cell lymphoma localized in the porta hepatis caused severe complications, including obstructive jaundice and acute renal failure. This highlights jaundice as a potential symptom of both Hodgkin and non-Hodgkin lymphoma.

Area of Science:

  • Hepatobiliary Medicine
  • Oncology
  • Nephrology

Background:

  • Lymphoma can present with diverse clinical manifestations.
  • Hepatic and porta hepatis involvement by lymphoma is uncommon.
  • Obstructive jaundice necessitates prompt diagnosis and management.

Observation:

  • A 65-year-old patient presented with obstructive jaundice.
  • Large-cell lymphoma was diagnosed, localized to the porta hepatis.
  • Complications included ascending cholangitis, septicemia, and acute renal failure.

Findings:

  • Localized porta hepatis lymphoma can cause severe biliary obstruction.
  • Lymphoma-induced jaundice can lead to critical systemic complications.
  • Ascending cholangitis and acute kidney injury are potential sequelae.

Implications:

  • Jaundice should be investigated for underlying malignancy, including lymphoma.
  • Early recognition of lymphoma in the porta hepatis is crucial for timely intervention.
  • This case broadens the understanding of lymphoma's varied clinical presentations.

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