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Updated: Aug 8, 2026

Determining the Phagocytic Activity of Clinical Antibody Samples
09:05

Determining the Phagocytic Activity of Clinical Antibody Samples

Published on: November 30, 2011

[Immunology in clinical practice. X. IgG receptors: structure, function and immunotherapy]

W L van der Pol1, J G van de Winkel

  • 1Afd. Immunologie, Academisch Ziekenhuis, Utrecht.

Nederlands Tijdschrift Voor Geneeskunde
|May 1, 1998
PubMed

Insights

Immunoglobulin G (IgG) receptors (Fc gamma R) link humoral and cellular immunity, driving immune responses and regulating IgG levels. Targeting these receptors shows promise in cancer immunotherapy.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Context:

  • Fc gamma receptors (Fc gamma R) bridge the humoral and cellular immune systems.
  • These receptors are expressed on various immune cells, including leukocytes and endothelial cells.
  • Soluble Fc gamma R in plasma modulate immune system activity.

Purpose:

  • To elucidate the diverse functions of Fc gamma receptors in immune responses.
  • To highlight the role of Fc gamma R in IgG regulation and transport.
  • To explore the therapeutic potential of Fc gamma R-mediated functions in cancer treatment.

Summary:

  • Fc gamma R on leukocytes mediate key immunological effector functions like phagocytosis and antibody-dependent cellular cytotoxicity (ADCC).
  • Fc gamma R on endothelial cells (Brambell receptor: FcRB) regulate blood IgG levels and maternal IgG transfer to fetuses.
  • Soluble Fc gamma R act as modulators within the immune system.

Impact:

  • Understanding Fc gamma R functions is crucial for comprehending immune system regulation.
  • Fc gamma R-targeted experimental immunotherapies demonstrate significant potential against hematological and solid tumors.
  • This research provides a foundation for developing novel immunotherapeutic strategies.

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