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CD5 negative diffuse mantle cell lymphoma with splenomegaly and bone marrow involvement

N D Bell1, J A King, C Kusyk

  • 1Department of Pathology, University of South Alabama Medical Center, Mobile 36617, USA.

Southern Medical Journal
|June 20, 1998
PubMed

Insights

This case study highlights an unusual CD5-negative mantle cell lymphoma, emphasizing the need for integrated diagnostic approaches including molecular and cytogenetic analysis for accurate lymphoma classification.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma.
  • Typical MCL is characterized by CD5 and CD10 negativity and the presence of t(11;14).
  • Atypical phenotypes can pose diagnostic challenges.

Observation:

  • A 78-year-old man presented with cervical adenopathy and splenomegaly.
  • Peripheral blood revealed lymphocytosis with slightly indented nuclei.
  • Lymph node and bone marrow biopsies showed lymphoid proliferation.

Findings:

  • Immunophenotyping demonstrated CD19+, CD20+, CD22+, lambda-restricted lymphocytes.
  • Importantly, CD5 and CD10 were negative.
  • Cytogenetic analysis confirmed the characteristic t(11;14) translocation.

Implications:

  • This case represents an unusual CD5-negative variant of mantle cell lymphoma.
  • Accurate diagnosis requires a combination of morphology, immunophenotyping, and cytogenetics.
  • Integrated diagnostic strategies are crucial for managing atypical lymphoma presentations.

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