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Updated: Aug 8, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions

J S Hayflick1, P Kilgannon, W M Gallatin

  • 1ICOS Corp., Bothell, WA 98021, USA. jhayflick@icos.com

Immunologic Research
|June 25, 1998
PubMed

Insights

Intercellular adhesion molecules (ICAMs) are crucial for immune cell communication and function. Understanding ICAMs aids in developing new therapies for various diseases.

Area of Science:

  • Cellular biology
  • Immunology
  • Molecular biology

Background:

  • Macromolecular cell adhesions transmit critical spatial and temporal information.
  • Intercellular adhesion molecules (ICAMs) are a key group of proteins involved in cell adhesion.
  • Recent discoveries have expanded the known members and functions of the ICAM family.

Purpose of the Study:

  • To highlight the growing understanding of ICAMs and their functions.
  • To emphasize the role of ICAMs in intracellular signaling.
  • To discuss the implications for therapeutic agent design.

Main Methods:

  • Review of current scientific literature on ICAMs.
  • Analysis of research on intercellular adhesion mechanisms.
  • Synthesis of findings related to ICAM signaling pathways.

Main Results:

  • ICAMs play a vital role in immune system function through cell adhesion.
  • Intracellular signaling events mediated by ICAMs are increasingly understood.
  • The expanding knowledge base facilitates the development of targeted therapies.

Conclusions:

  • Continued research into ICAMs is essential for advancing immunology.
  • Understanding ICAM functions provides a basis for novel therapeutic strategies.
  • ICAM-targeted therapies hold promise for treating diverse disease states.

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