Related Experiment Video

Updated: Aug 8, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

CD73 and adhesion of B-cells to follicular dendritic cells

L Airas1

  • 1MediCity Research Laboratory, University of Turku, Finland. laura.airas@utu.fi

Leukemia & Lymphoma
|June 25, 1998
PubMed

Insights

CD73 (ecto-5'-nucleotidase) plays a key role in immune cell interactions and maturation. This marker influences lymphocyte binding to endothelial cells and B-cell adhesion to follicular dendritic cells (FDC).

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • CD73, or ecto-5'-nucleotidase, is a recognized marker for lymphocyte maturation.
  • It participates in crucial cellular processes including intracellular signaling, proliferation, and activation.

Purpose of the Study:

  • To review the multifaceted role of CD73 in immune cell regulation.
  • To discuss the involvement of CD73 in lymphocyte interactions with endothelial cells and B-cells with follicular dendritic cells (FDC).

Main Methods:

  • Literature review of studies investigating CD73 function.
  • Analysis of CD73 expression patterns in secondary lymphoid tissues.

Main Results:

  • CD73 mediates lymphocyte binding to endothelial cells in vitro.
  • CD73 controls the adhesion between germinal center B-cells and FDC.
  • CD73 is expressed on FDC and resting mantle zone B-cells, but not on germinal center B-cells.

Conclusions:

  • CD73 is critical for regulating B-cell-FDC interactions.
  • The expression and function of CD73 are integral to B-cell maturation processes within lymphoid tissues.

More Related Videos

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols08:31

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

Published on: October 18, 2016

Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...