[Primary cutaneous B-cell lymphoma: present views]

Area of Science:

• Dermatology
• Hematology
• Oncology

Context:

• Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of malignant neoplasms.
• Distinguishing primary CBCLs from secondary involvement or pseudolymphoma is crucial for accurate diagnosis and management.
• Recent advancements have led to the definition of new entities within CBCL classification.

Purpose:

• To describe the evolution of classification systems for primary cutaneous B-cell lymphomas.
• To highlight newly defined entities such as primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicular centre cell lymphoma, and large B-cell lymphoma of the legs.
• To provide an overview of the diagnostic criteria and clinical significance of these lymphomas.

Summary:

• The majority of lymphoproliferative B-cell cutaneous lesions are confirmed as primary lymphomas of the skin.
• The classification of primary cutaneous B-cell lymphomas has been refined, incorporating newly identified subtypes.
• Key entities discussed include primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicular centre cell lymphoma, and leg-type large B-cell lymphoma.

Impact:

• Accurate classification improves diagnostic precision for cutaneous B-cell lymphomas.
• Understanding newly defined entities aids in tailored treatment strategies.
• Most primary cutaneous B-cell lymphomas exhibit a favorable response to therapy and a good prognosis, offering hope for affected patients.