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Control of lymphocyte function through CD27-CD70 interactions

S M Lens1, K Tesselaar, M H van Oers

  • 1Department of Immunobiology, CLB, Sanquin Blood-foundation, Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Plesmanlaan 125, Amsterdam, CX, 1066, The Netherlands.

Seminars in Immunology
|November 25, 1998
PubMed

Insights

The CD27-CD70 pathway, primarily on lymphocytes, is crucial for immune responses. Soluble CD27 (sCD27) indicates immune activation and correlates with tumor load in B cell malignancies.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • CD27 and its ligand CD70 expression is mainly restricted to lymphocytes.
  • CD27 expression requires antigen receptor ligation, while CD70 induction needs co-stimulatory or pro-inflammatory signals.
  • Both membrane-bound and soluble forms of CD27 (sCD27) exist during immune responses.

Purpose of the Study:

  • To investigate the role of CD27-CD70 interactions in regulating antigen-primed lymphocyte populations.
  • To explore the utility of soluble CD27 (sCD27) as a biomarker for immune activation and B cell malignancies.

Main Methods:

  • Analysis of CD27 and CD70 expression regulation on lymphocytes.
  • Measurement of soluble CD27 (sCD27) levels in body fluids.
  • Correlation analysis of sCD27 levels with tumor load in B cell malignancies.

Main Results:

  • CD27 and CD70 expression are predominantly lymphocyte-specific and differentially regulated.
  • Soluble CD27 (sCD27) is detectable in body fluids and reflects immune activation.
  • Elevated sCD27 serum concentrations correlate strongly with tumor burden in B cell malignancies.

Conclusions:

  • CD27-CD70 interactions between activated lymphocytes may modulate the size and function of antigen-primed populations in vivo.
  • Soluble CD27 (sCD27) serves as a valuable marker for monitoring immune status and disease progression in B cell malignancies.

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