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Intussuception as a complication of chronic lymphocytic leukemia

H Handa1, H Murakami, J Tamura

  • 1Department of Medicine, Kusatsu Branch Hospital, Gunma University Hospital, Japan.

Journal of Medicine
|December 29, 1998
PubMed

Insights

Chronic lymphocytic leukemia (CLL) can lead to small intestine intussusception caused by tumor infiltration. This complication may occur even with controlled white blood cell counts.

Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy.
  • Intussusception is a rare but serious gastrointestinal condition.

Observation:

  • A case study of a 58-year-old man with CLL who developed small intestine intussusception is presented.
  • The intussusception was caused by a tumor identified as diffuse small lymphocytic lymphoma.

Findings:

  • Histopathological analysis confirmed the tumor was consistent with CLL (B-cell type).
  • The tumor showed a positive response to CHOP therapy, with residual tumor size reduction.
  • CLL cell infiltration into the small intestine is proposed as the cause of intussusception.

Implications:

  • Intussusception is a potential complication of CLL, even with managed white blood cell (WBC) counts.
  • Lymphomas and other tumors can present as polypoid lesions, leading to intussusception.
  • This case highlights the importance of considering intussusception in CLL patients presenting with relevant symptoms.

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