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[Immune responses of tuberculosis patients]

J Honda, K Oizumi

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |January 12, 1999
    PubMed

    Insights

    Tuberculosis immunity involves Th1 cytokines, but Th2 cells, identified by IL-4, were found in TB patients. Gamma delta T cells decreased, yet showed varied responses to PPD.

    Area of Science:

    • Immunology
    • Microbiology

    Context:

    • Tuberculosis (TB) immunity is linked to Th1 cytokine profiles.
    • Experimental models show Th2 components can impair immunity and cause disease pathology.

    Purpose:

    • To investigate the presence of Th2 cells in peripheral blood of TB patients.
    • To analyze gamma delta (γδ) T cell populations and function in TB.

    Summary:

    • Interleukin-4 (IL-4) producing Th2 cells were detected in both CD4+ and CD4- T cells in TB patients.
    • A decrease in Vγ9-expressing γδ T cells was observed in TB patients.
    • Some Vγ9+ γδ T cells from TB patients exhibited enhanced proliferative responses to purified protein derivative (PPD) compared to controls.

    Impact:

    • Findings suggest a potential role for Th2 cells in TB pathogenesis.
    • The altered γδ T cell dynamics in TB warrant further investigation to fully elucidate their function in the disease.

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