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Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class

A Regnault1, D Lankar, V Lacabanne

  • 1Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France.

The Journal of Experimental Medicine
|January 20, 1999
PubMed

Insights

Fc receptors (FcgammaR) on dendritic cells (DCs) trigger DC maturation and enhance antigen presentation on MHC class I and II molecules. Immune complexes (ICs) containing IgG are key for sensitizing DCs to prime T cells.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Dendritic cells (DCs) express Fc receptors for immunoglobulin G (FcgammaR).
  • FcgammaR binding of antigen-IgG complexes (immune complexes, ICs) facilitates antigen uptake and MHC class II presentation.

Purpose of the Study:

  • To investigate additional functions of FcgammaRs in murine dendritic cells.
  • To explore the role of FcgammaRs in dendritic cell maturation and antigen presentation pathways.

Main Methods:

  • Analysis of FcgammaR-associated gamma chain function in dendritic cells.
  • Assessment of MHC class I and MHC class II antigen presentation pathways.
  • Investigation of proteasomal degradation and transporter associated with antigen processing (TAP1-TAP2) involvement.

Main Results:

  • FcgammaRs induce dendritic cell maturation.
  • FcgammaRs promote efficient MHC class I-restricted presentation of exogenous IgG-complexed antigens.
  • Both FcgammaR functions depend on the FcgammaR-associated gamma chain and are specific to immature DCs, requiring proteasomal degradation and TAP1-TAP2.

Conclusions:

  • Immune complexes (ICs) enhance dendritic cell maturation and antigen presentation via FcgammaRs.
  • ICs promote efficient priming of CD4(+) helper and CD8(+) cytotoxic T lymphocytes by sensitizing DCs for MHC class I and II presentation.

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