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Published on: January 7, 2019
[Testicular lymphoma in two patients with AIDS and two without AIDS]
L G Pérez-Santos1, A Gamboa-Domínguez, H Guzmán-Rodríguez
1Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F., México.
Insights
Testicular non-Hodgkin lymphomas are aggressive in AIDS patients. These B-cell lymphomas, negative for Epstein-Barr virus, showed poor outcomes in HIV-positive individuals.
Area of Science:
- Oncology
- Hematology
- Immunology
Background:
- Testicular non-Hodgkin lymphoma (NHL) is rare.
- Clinical, morphological, and immunophenotypic characteristics require further elucidation.
Purpose of the Study:
- To describe the clinical, morphological, and immunophenotypic characteristics of testicular NHL.
- To report on the follow-up of patients diagnosed with testicular NHL at a referral center.
Main Methods:
- Retrospective review of testicular lymphoma cases from 1987 to 1997.
- Immunohistochemical studies including CD45, CD20, CD43, Epstein-Barr virus latent membrane protein, and UCHL-1.
- Statistical analysis using the Fisher exact test.
Main Results:
- Four cases of testicular lymphoma (7.5% of testicular tumors) were identified.
- Two cases occurred in patients with AIDS, presenting with more aggressive local invasion and systemic progression.
- All four lymphomas were B-cell lineage, negative for Epstein-Barr virus latent membrane protein.
- Non-AIDS patients had favorable outcomes, while AIDS patients died within 1-3 months.
Conclusions:
- Testicular NHL in this cohort was of B-cell origin and EBV-negative.
- AIDS-associated testicular lymphoma exhibited a more aggressive clinical course and poorer prognosis.
Objective:
To describe the clinical, morphological and inmunophenotypic characteristics and followup of testicular non Hodgkin lymphomas seen in a referral center.
Methods:
We reviewed the cases of testicular lymphoma seen from 1987 to 1997. We obtained data of laboratory tests, radiological findings, clinical course, treatment and new immunohistochemical studies (CD45, CD20, CD43, Epstein-Barr virus latent membrane protein and antibodies UCHL-1). We performed a blind analysis to identify the morphological variables associated to the clinical course. The Fisher exact test was used for statistical significance identification.
Results:
53 patients with testicular tumors were seen. Four of them were lymphomas (7.5%) with a mean age of 47 years (range 33-73) and two of the four had AIDS. A comparative analysis showed major local invasion of surgical margins and systemic progression in the AIDS cases. Immunohystochemical testing showed that the neoplasia was formed by B cells negative for Epstein-Barr virus latent membrane protein. The two patients without AIDS showed no evidence of the disease after 64 and 144 months of followup. The AIDS cases died one and three months after the diagnosis of testicular lymphoma was made.
Conclusions:
The four cases of testicular lymphoma were of B cell lineage without immunohystochemical expression for Epstein-Barr virus latent membrane protein. There was a more aggressive clinical course in the cases associated with AIDS.
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