Video Experimental Relacionado

Updated: Jan 14, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Colecistitis aguda asociada con colangitis esclerosante relacionada con IgG4: reporte de un caso

Shoichiro Yoneyama¹, Ichitaro Horiuchi², Nobukazu Sasaki²

¹Department of Gastroenterology, Nagano Red Cross Hospital.

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

|January 12, 2026

Insights

La colangitis esclerosante relacionada con la inmunoglobulina G4 (IgG4-SC) puede causar problemas en los conductos biliares y colecistitis aguda. El tratamiento con esteroides resolvió eficazmente tanto la IgG4-SC como la colecistitis en un paciente.

Área de la Ciencia:

Gastroenterología
Hepatología
Inmunología

Sus antecedentes:

La colangitis esclerosante relacionada con la inmunoglobulina G4 (IgG4-SC) es una afección inflamatoria fibrótica que puede afectar el sistema biliar.
Es clínicamente importante distinguir la IgG4-SC de otras causas de estenosis biliar, como el colangiocarcinoma.
La IgG4-SC puede presentarse con diversas manifestaciones biliares, incluida la afectación del conducto biliar común y del conducto cístico.

Objetivo del estudio:

Informar un caso de colecistitis aguda secundaria a colangitis esclerosante relacionada con la inmunoglobulina G4 (IgG4-SC).
Destacar los desafíos diagnósticos y el curso clínico de la IgG4-SC que afecta al sistema biliar.
Demostrar la eficacia de la terapia con esteroides en el manejo de las complicaciones biliares relacionadas con IgG4-SC.

Principales métodos:

Un paciente varón de 72 años presentó ictericia y estenosis biliar hiliar.
El estudio diagnóstico incluyó colangiografía, ultrasonografía intraductal y medición de los niveles séricos de inmunoglobulina G4 (IgG4).
Se utilizaron ultrasonografía endoscópica y colangiografía para evaluar la colecistitis aguda y la estenosis del conducto cístico.

Principales resultados:

Los hallazgos iniciales sugirieron colangiocarcinoma, pero luego se revisaron a IgG4-SC basándose en niveles elevados de IgG4 y afectación de otros órganos.
El paciente desarrolló colecistitis aguda con estenosis del conducto cístico, probablemente secundaria a IgG4-SC.
Tanto la IgG4-SC como la colecistitis aguda mostraron una mejora significativa tras el tratamiento con esteroides.

Conclusiones:

La IgG4-SC puede provocar obstrucción biliar y complicaciones como la colecistitis aguda.
El diagnóstico y manejo oportunos, incluida la terapia con esteroides, son cruciales para obtener resultados favorables en la IgG4-SC.
Este caso subraya la importancia de considerar la IgG4-SC en el diagnóstico diferencial de las estenosis biliares y sus complicaciones asociadas.

Read full analysis

Abstract:

A 72-year-old male patient with jaundice and hilar bile duct stenosis, initially suspected to have cholangiocarcinoma, was referred to our hospital. Subsequent cholangiography revealed bile duct stenosis improvement, and intraductal ultrasonography demonstrated homogeneous bile duct wall thickening. The increased serum immunoglobulin G4 (IgG4) levels and the presence of other organ lesions possibly indicated to IgG4-related sclerosing cholangitis (IgG4-SC). After 2 months, the patient developed acute cholecystitis. Endoscopic ultrasonography revealed circumferential wall thickening that extended from the common bile duct to the cystic duct. Cholangiography demonstrated cholecystic duct stenosis. The cholecystitis might have originated from bile stasis caused by cystic duct stenosis associated with IgG4-SC. Consequently, both IgG4-SC and the cholecystitis improved with steroid treatment.

Palabras clave:

colangitis esclerosante relacionada con IgG4 colecistitis aguda estenosis biliar tratamiento con esteroides reporte de caso

Más Videos Relacionados

The Role of Indocyanine Green Fluorescence in Complex Laparoscopic Cholecystectomy Navigation

The Role of Indocyanine Green Fluorescence in Complex Laparoscopic Cholecystectomy Navigation

Published on: January 31, 2025

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture

Published on: November 25, 2025

Videos de Conceptos Relacionados

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

Acute Pancreatitis II: Clinical Manifestations and Management

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...