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奇孔古尼亚病毒感染会通过MARCO破坏淋巴结的淋巴内皮细胞组成和功能

Cormac J Lucas, Ryan M Sheridan, Glennys V Reynoso

    bioRxiv : the preprint server for biology
    |October 24, 2023
    PubMed

    Insights

    奇孔古尼亚病毒 (CHIKV) 感染通过向淋巴内皮细胞 (LECs) 来破坏淋巴结组织. 这会损害免疫细胞功能和抗原获取,阻碍身体对感染的反应.

    科学领域:

    • 免疫学 免疫学 免疫学
    • 病毒学 病毒学
    • 细胞生物学 细胞生物学

    背景情况:

    • 奇孔古尼亚病毒 (CHIKV) 感染破坏了排水淋巴结 (dLN) 组织,导致B细胞重新定位,B细胞-T细胞边界丧失和淋巴细胞枯竭.
    • 在CHIKV感染期间,炎症性髓状细胞透到淋巴结中,导致其失调.

    结论:

    • CHIKV感染直接影响LECs,启动炎症级联并损害淋巴结结构和功能.
    • CHIKV和MARCO表达的LEC之间的相互作用在调节淋巴结内的早期免疫反应方面发挥着至关重要的作用.
    • 损坏的LEC功能,包括减少的抗原获取,有助于在CHIKV感染期间观察到的整体免疫失调.
    抽象的

    No abstract available in PubMed .

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