相关实验视频

Updated: Jul 11, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

879

与对比介质相关的甲状腺功能障碍:基于FDA不良事件报告系统的现实世界药监测研究

Lu Huang1,2,3, Yan Luo1,2,4, Zhen-Lin Chen3

  • 1Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Heliyon
|November 13, 2023
PubMed

Insights

对比介质 (ICM) 可以导致甲状腺功能障碍,包括甲状腺功能低下和甲状腺功能过高,通常在服用后30天内. 约迪克桑醇显示最高风险,需要对高风险药物进行甲状腺功能监测.

科学领域:

  • 内分泌学 在内分泌学.
  • 放射学 放射学是一门学科.
  • 药物监督 药物监督 药物监督

背景情况:

  • 对比介质 (ICM) 广泛用于医学成像.
  • ICM的使用可能会影响甲状腺功能.
  • 了解ICM诱导的甲状腺功能障碍的特定风险对于患者的安全至关重要.

研究的目的:

  • 分析与ICM相关的甲状腺功能障碍的特征.
  • 为了确定构成甲状腺功能障碍风险较高的特定ICM药物.
  • 评估ICM相关甲状腺事件的时间关系和严重程度.

主要方法:

  • 使用了FDA不良事件报告系统 (FAERS) 数据库.
  • 使用不成比例的分析来检测甲状腺功能障碍的安全信号.
  • 对报告病例的临床特征进行了描述性分析.

主要成果:

  • 确定了83份与ICM相关的甲状腺功能障碍报告.
  • 在ICM中,甲状腺功能低下症 (ROR=2.21) 和甲状腺功能过高症 (ROR=3.49) 的报告显著增加.
  • 约迪克桑醇在甲状腺功能低下 (ROR=9.47) 和甲状腺功能增强 (ROR=5.44) 两方面都显示出最高的信号.
  • 大多数病例发生在ICM给药后的30天内.
  • 甲状腺功能障碍症 (12/26) 的严重结局比甲状腺功能障碍症 (2/35) 更频繁.

结论:

  • 不同的ICM药物携带着不同的甲状腺功能障碍风险,约迪克桑醇是一个值得关注的关注点.
  • 在ICM之后的甲状腺功能障碍通常在第一个月内表现出来.
  • 建议在服用后监测甲状腺功能,特别是在高风险的ICM药物中.
抽象的

No abstract available in PubMed .

更多相关视频

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

641
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.6K

相关概念视频

Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
249
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
12
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
860
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
21
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
341