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不同器官系统中脂聚糖诱导的炎症变化的肠道显微镜 - - 范围审查

Cassidy Scott1,2, Daniel Neira Agonh3, Hannah White2

  • 1Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H1X5, Canada.

International journal of molecular sciences
|November 25, 2023
PubMed

Insights

肠道显微镜 (IVM) 可视化实时的细胞相互作用 in vivo. 本综述概述了IVM对各种器官中脂聚糖 (LPS) 诱导的炎症的成像,强调其在研究免疫反应中的作用.

科学领域:

  • 免疫学 免疫学 免疫学
  • 生理学 生理学 生理学
  • 显微镜的使用方法

背景情况:

  • 肠道显微镜 (IVM) 能够实时观察生物体内的生物过程.
  • 活体外和体外模型缺乏对理解复杂细胞相互作用至关重要的生理背景.
  • IVM对于研究免疫反应至关重要,特别是微循环中的白细胞-内皮细胞相互作用.

研究的目的:

  • 为研究脂聚糖 (LPS) 诱导的炎症提供肠内显微镜 (IVM) 应用的概述.
  • 总结IVM研究的发现,研究各种器官系统的炎症反应.
  • 突出IVM在各种病理模型中的实用性.

主要方法:

  • 关于IVM研究的现有文献审查,涉及LPS诱导的炎症.
  • 对IVM成像技术进行分析,以在体内可视化细胞动态.
  • 在大脑,肠道,膀和肺部模型中进行的研究数据的综合.

主要成果:

  • IVM有效地可视化了LPS在多个器官中诱导的急性炎症变化.
  • 白细胞招募和微循环变化是关键的可观察现象.
  • 该技术允许详细描述炎症期间免疫细胞行为的特征.

结论:

  • 肠道显微镜是研究LPS诱导的炎症的必不可少的工具.
  • IVM提供了对免疫细胞动态和微血管反应的关键见解.
  • 审查的研究表明,IVM在不同器官系统的广泛适用性,用于炎症研究.
抽象的

No abstract available in PubMed .

关键词:
这是一种炎症炎症炎症炎症.静脉内成像检查 静脉内成像检查血清细胞是白细胞.脂多糖类糖化物 (Lipopolysaccharide) 是一种脂多糖类糖.微循环是一种微循环.

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