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慢性淋巴细胞白血病患者的B细胞子组和免疫检查点表达

Aviwe Ntsethe1, Zekhethelo Alondwe Mkhwanazi1, Phiwayinkosi Vusi Dludla2,3

  • 1School of Laboratory Medicine and Medical Sciences (SLMMS), University of KwaZulu-Natal, Durban 4000, South Africa.

Current issues in molecular biology
|March 27, 2024
PubMed

Insights

在慢性淋巴细胞白血病 (CLL) 中,免疫检查点编程死亡-1 (PD-1) 和细胞毒性T淋巴细胞相关蛋白4 (CTLA-4) 在B细胞上升. 然而,在CLL患者中,这些检查点水平与β-2微球蛋白 (B2M) 不相关.

科学领域:

  • 免疫学 免疫学 免疫学
  • 血液学 血液学 血液学
  • 在瘤学瘤学.

背景情况:

  • 慢性淋巴细胞白血病 (CLL) 涉及B细胞功能障碍.
  • 像PD-1和CTLA-4这样的免疫检查点在CLL上调节,可能与B2M等预后标志物有关.

研究的目的:

  • 为了研究CLL患者B细胞子集的免疫检查点表达.
  • 确定免疫检查点水平与CLL中的B2M之间的相关性.

主要方法:

  • 多色流细胞计用于分析B细胞子集和免疫检查点表达.
  • 与酶相关的免疫吸收试验 (ELISA) 测量了基底B2M水平.
  • 包括21名CLL患者和12名健康对照.

主要成果:

  • 与对照组相比,CLL患者的激活B细胞水平较高 (p < 0.001).
  • 在CLL患者的激活和记忆B细胞上观察到PD-1和CTLA-4的表达增加 (p <0.05).
  • 在调整年龄和性别后,没有发现B2M水平和B细胞子集上的免疫检查点表达之间有显著的关联.

结论:

  • 患有CLL的患者在激活和记忆B细胞上显示PD-1和CTLA-4的升高.
  • 在研究的CLL队列中,B2M水平与B细胞上的这些免疫检查点表达不相关.
抽象的

No abstract available in PubMed .

关键词:
B 细胞子集 B 细胞子集贝塔-2微型血球蛋白慢性淋巴细胞白血病 慢性淋巴细胞白血病细胞毒性T淋巴细胞相关蛋白4 4免疫检查点的检查点.编程死亡蛋白 1 1

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