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CD74是激活CD4+T细胞上的一个功能MIF受体

Lin Zhang1, Iris Woltering1, Mathias Holzner1

  • 1Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU University Hospital (LMU Klinikum), Ludwig-Maximilians-Universität (LMU) München, Feodor-Lynen-Straße 17, 81377, Munich, Germany.

Cellular and molecular life sciences : CMLS
|July 11, 2024
PubMed

Insights

CD74是巨细胞迁移抑制因子 (MIF) 的受体,在激活的T细胞上升调节,并在MIF诱导的T细胞迁移中发挥作用. 它的表面表达与严重的COVID-19疾病有关.

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 分子医学是分子医学.

背景情况:

  • CD74传统上在MHC II抗原呈现中起作用.
  • CD74是巨细胞迁移抑制因子 (MIF) 的高亲和感受体.
  • 目前尚不清楚CD74在T细胞中的作用及其与MIF的相互作用.

研究的目的:

  • 在人类CD4+T细胞激活过程中调查CD74表达和MIF受体调节.
  • 为了确定CD74在MIF诱导的T细胞迁移和功能中的功能相关性.
  • 探索CD74表达和COVID-19疾病严重程度之间的联系.

主要方法:

  • 流细胞测量用于T细胞的受体概况.
  • 西方斑块,免疫组织化学和对CD74表达的OMIC数据的分析.
  • 3D矩阵活细胞成像和受体抑制剂用于研究T细胞迁移.
  • 接近结合试验用于可视化受体异构复合体.
  • 来自COVID-19患者的T细胞样本的分析.

主要成果:

  • 休息的CD4+T细胞表达细胞内CD74和表面CXCR4;激活的T细胞上调细胞表面CD74.
  • CD74和CXCR4在MIF诱导的CD4+T细胞迁移中具有因果关系.
  • MIF治疗导致CD74/CXCR4异构体的减少,这表明内部化.
  • 在CD4+和CD8+T细胞上增加CD74表面表达与严重的COVID-19相关.

结论:

  • CD74是一种在激活的人类T细胞上的新型,功能性的MIF受体.
  • CD74作为CD4+ T细胞的MHC II独立激活标志物.
  • 在T细胞激活过程中,MIF-T细胞受体网络受到动态调节,在COVID-19病变发生过程中具有重要意义.
抽象的

No abstract available in PubMed .

关键词:
非典型的化学.CD74/不变链 CD74/不变链 CD74/不变链在CXCR4中,CXCR4是最常见的.多元期权基金和多元期权基金.巨细胞迁移抑制因子在T细胞,T细胞.

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