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在IMID患者中,扩大衰老的CD8T细胞与明显的炎症性细胞因子有关

Marie Naigeon1, Samuel Bitoun2, Matthieu Roulleaux Dugage1,3

  • 1INSERM US23/CNRS UAR 3655, Laboratoire d'Immunomonitoring en Oncologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

Clinical and experimental immunology
|September 8, 2025
PubMed

Insights

衰老的CD8T细胞 (T8sen) 在免疫媒介炎症疾病 (IMID) 中积累,这表明在这些疾病中免疫衰老是常见的. 抗TNF治疗没有影响RA和SPA患者的T8sen水平.

科学领域:

  • 免疫学 免疫学 免疫学
  • 老年学是一门学科.
  • 类风湿病学 类风湿病学

背景情况:

  • 免疫衰老,以衰老的T细胞为特征,在慢性疾病中越来越多地被认可.
  • 在免疫媒介性炎症性疾病 (IMIDs) 中T细胞衰老的作用仍然不完全理解.

研究的目的:

  • 在风湿性关节炎 (RA) 和脊椎关节炎 (SpA) 患者中研究老化的T细胞 (T4sen和T8sen) 的比例.
  • 评估抗TNF治疗对T细胞衰老的影响.
  • 探索T细胞衰老,细胞因子和疾病特征之间的关联.

主要方法:

  • 流细胞测量用于量化在RA,SPA,Sjögren综合征 (SjD),健康捐赠者和癌症患者中循环T4sen和T8sen的比例.
  • 在基线测量了细胞因子水平 (IL-6,IP-10).
  • 患者在基线和开始抗TNF治疗3个月后进行了评估.

主要成果:

  • 与健康捐赠者和癌症患者相比,T8sen,但不是T4sen,在IMID患者中显著累积.
  • 对CMV的阳性与T8sen积累的增加有关.
  • 在SJD患者中,T8sen水平与SPA中的IL-6和SJD患者中的IP-10相关.
  • 抗TNF治疗没有改变RA和SpA患者的T8sen比例,非响应者增加的趋势.

结论:

  • 衰老的CD8T细胞在IMID患者中被丰富,表明免疫衰老是这些慢性炎症疾病的共同特征.
  • T8sen与特定的炎症性细胞因子的关联表明,T8sen在IMIDs内塑造免疫反应中的作用.
抽象的

No abstract available in PubMed .

关键词:
CD8 T 细胞 CD8 T 细胞斯约格伦氏病是斯约格伦氏病的一种疾病.这是一种抗TNF的药物.类风湿性关节炎 类风湿性关节炎衰老是一种老化.脊柱性关节炎 (spondyloarthritis) 是一种关节炎.

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