对比剂对甲状腺功能的短期影响:一个前性队列研究

Lingling Peng1, Shujin Fan2, Feifei Lai3

  • 1Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Annals of medicine
|September 18, 2025
PubMed

Insights

含的对比介质 (ICM) 可以导致暂时的甲状腺功能障碍,特别是在患有甲状腺结节的患者中. 大多数中国患者在对比剂暴露后一个月内自然恢复.

科学领域:

  • 内分泌学 在内分泌学.
  • 放射学 放射学是一门学科.
  • 公共卫生 公共卫生

背景情况:

  • 在医学成像过程中使用含的对比剂 (ICM) 存在过量摄入的风险.
  • 在中国人群中,ICM对甲状腺功能的潜在短期影响尚不清楚.

研究的目的:

  • 研究ICM暴露对中国人口甲状腺功能的短期影响.
  • 为了确定尿液中含量与对比剂剂量之间的关系.
  • 评估ICM暴露后甲状腺功能恢复的情况.

主要方法:

  • 在200名接受静脉注射ICM的患者中,甲状腺功能在暴露前,1周和输液后1个月被评估.
  • 分析了尿液中度 (UIC) 和对比剂 (CA) 的剂量.
  • 患有甲状腺功能障碍的患者被跟踪了3个月.

主要成果:

  • 尿中的水平在ICM后1周达到峰值,与自由甲状腺素 (FT4) 呈现微弱的正相关性.
  • 较高的对比剂剂量与较低的抗甲状腺过氧化酶抗体 (TPOAb) 水平存在弱相关性.
  • 患有甲状腺结节的患者患甲状腺功能障碍症的风险增加 (OR = 2.1491,p=0.0465).

结论:

  • 暴露于ICM可以暂时增加亚临床甲状腺功能障碍的风险,特别是在患有先前存在甲状腺结节的患者中.
  • 观察到的甲状腺功能异常通常是暂时的,大多数患者在没有干预的情况下在3个月内自发恢复.
抽象的

No abstract available in PubMed .

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