患有疑似免疫检查点抑制剂相关心肌炎的患者的耐火性心室失常:一个病例报告

Xinhao Jin1, Rui Zheng1

  • 1Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.

PubMed

Insights

免疫检查点抑制剂 (ICI) 可以引起罕见但严重的心肌炎. 早期临床识别对免疫治疗患者至关重要,特别是当成像或活检等最终诊断由于患者的不稳定性而不可行时.

科学领域:

  • 心脏病学 心脏病学
  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学

背景情况:

  • 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗.
  • 一种罕见但严重的ICI并发症是心肌炎,心肌的炎症.
  • 诊断ICI相关心肌炎是一个挑战,特别是在不稳定的患者.

研究的目的:

  • 为了突出免疫检查点抑制剂相关心肌炎的诊断困难.
  • 强调临床警在诊断免疫疗法的心脏毒性时的重要性.

主要方法:

  • 一个65岁的患有食道癌症的男性接受托里帕利马布 (PD-1抑制剂) 治疗的病例报告.
  • 临床表现包括耐火性腹腔动心,升高的I型热素,以及心声学上的减少喷射分数.
  • 由于血液动力学不稳定的诊断限制,排除了心脏MRI或活检.

主要成果:

  • 患者发生了与ICI相关的心肌炎一致的严重心脏事件.
  • 用高剂量甲基前素,免疫球蛋白和抗失常药物治疗的疗效有限.
  • 患者最终在治疗限制和治疗停止后去世.

结论:

  • 这一案例说明了疑似ICI相关心肌炎的诊断复杂性.
  • 在接受免疫治疗的患者中,早期识别免疫媒介心脏毒性至关重要.
  • 当不能进行确切的诊断程序时,临床怀疑至关重要.
抽象的

No abstract available in PubMed .

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