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细胞因子释放综合征:一个病例报告

Inês Filipa Silva1, Sofia Gomes Salgueira1, Ana Isabel Loureiro1

  • 1Pulmonology Department, Unidade Local de Saúde de Trás-os-Montes e Alto Douro, Vila Real, PRT.

Cureus
|December 15, 2025
PubMed

Insights

免疫检查点抑制剂可能导致细胞因子释放综合征 (CRS),严重的免疫反应. 在接受这些疗法的患者中,早期识别和皮质类固醇治疗对于管理CRS至关重要.

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 免疫检查点抑制剂 (ICI),如 pembrolizumab 在癌症治疗中至关重要.
  • 严重的免疫相关不良事件,包括细胞因子释放综合征 (CRS),可以发生在ICI.
  • 细胞因子释放综合征涉及过度免疫激活和升高的介素-6 (IL-6) 水平.

研究的目的:

  • 在接受 pembrolizumab 和 pemetrexed 维持治疗的患者中报告细胞因子释放综合征 (CRS) 的病例.
  • 突出CRS的诊断挑战和有效管理.
  • 强调皮质类固醇在治疗ICI诱导的CRS中的作用.

主要方法:

  • 一个71岁的男性患有IVB期肺腺癌的病例报告.
  • 在维持治疗期间,患者呈现急性混乱状态和发烧.
  • 在排除其他原因后,CRS的诊断得到了高血清IL-6水平的支持.

主要成果:

  • 患者表现出与CRS一致的症状,包括发烧和神经变化.
  • 血清IL-6水平在270 pg/mL时显著升高.
  • 系统性皮质类固醇治疗导致发烧和神经症状的缓解.

结论:

  • 细胞因子释放综合征 (CRS) 是免疫检查点抑制剂的潜在严重不良事件.
  • 早期诊断和及时管理,特别是用皮质类固醇,对于有利的结果至关重要.
  • 这一案例强化了皮质类固醇在控制ICI诱导的CRS方面的疗效.
抽象的

No abstract available in PubMed .

关键词:
临床病例报告细胞因子释放综合征 细胞因子释放综合征对罕见病例的诊断.介质蛋白 (il) -6 的存在.互乐金-6是其中的一种.这就是Pembrolizumab.

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