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CD147/Basigin:从整合性的分子枢纽到翻译性的治疗点

Xiang-Min Yang1,2, Huijie Bian1,2, Zhi-Nan Chen1,2

  • 1Department of Cell Biology, National Translational Science Center for Molecular Medicine, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 27, 2025
PubMed

Insights

CD147 (Basigin/EMMPRIN) 是癌症和疾病的关键调节剂. 本综述详细介绍了其结构,功能和作为治疗点的潜力.

科学领域:

  • 分子生物学分子生物学
  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.

背景情况:

  • 免疫球蛋白超级家族成员CD147 (Basigin/EMMPRIN) 调节精子生成和神经功能等生理过程.
  • 病理性CD147过度表达驱动瘤进展,免疫逃避和代谢重编程,作为预后生物标志物.
  • CD147充当病原体进入受体,并与心血管,自身免疫和神经退行性疾病有关.

研究的目的:

  • 审查CD147.7的分子结构,异形,翻译后修改和信号通路.
  • 突出CD147在癌症,感染,自身免疫和心血管疾病中的多样性作用.
  • 讨论挑战,并提出针对CD147作为精密生物标志物和治疗剂的策略.

主要方法:

  • 文献综述综合了关于CD147.7的当前研究.
  • 分析CD147与MCT,整蛋白和CyPA等关键分子的相互作用.
  • 检查CD147在各种病理条件和疾病模型中的作用.

主要成果:

  • CD147作为一种"能量结构合器",将代谢流与形态遗传可塑性联系起来.
  • 它调节关键的细胞过程,并有助于疾病的发病.
  • CD147的多方面的作用强调了它在多个科学领域的意义.

结论:

  • CD147是一种关键的调节器,在健康和疾病中具有多种功能.
  • 了解CD147的结构和信号传递对于开发向疗法至关重要.
  • 解决"特异性悖论"是有效利用CD147作为生物标志物和治疗点的关键.
抽象的

No abstract available in PubMed .

关键词:
自身免疫性疾病是一种自身免疫性疾病.CD147 是一个CD147 CD147 是一个CD147传染病 传染病 传染病矩阵金属蛋白酶 (MMP) 是一种瘤微环境是一个微环境.

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