行为交叉器官神经免疫学

Xuanming Guo1, Scott J Russo1

  • 1Nash Family Department of Neuroscience; Brain-Body Research Institute; and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; email: xuanming.guo@mssm.edu, scott.russo@mssm.edu.

Annual review of immunology
|February 23, 2026
PubMed

Insights

行为交叉器官神经免疫学 (CONB) 网络将行为视为全身免疫-大脑相互作用. 这个框架将系统健康与大脑功能联系在一起,为精准医学提供了新的途径.

科学领域:

  • 神经免疫学 神经免疫学
  • 系统生物学 系统生物学
  • 行为神经科学 行为神经科学

背景情况:

  • 神经免疫通信涉及细胞因子-神经信号传递,质-免疫相互作用和神经内分泌通路.
  • 周围器官在这种通信网络中充当关键节点.
  • 了解这些相互作用是解读复杂行为的关键.

研究的目的:

  • 介绍行为跨器官神经免疫学 (CONB) 网络框架.
  • 重新构思行为作为分布式,全身免疫-大脑网络的新兴属性.
  • 整合神经免疫通信和外周器官信号的知识.

主要方法:

  • 概念框架的发展.
  • 整合关于神经免疫和神经内分泌通路的现有知识.
  • 分析外围器官作为网络节点的作用.

主要成果:

  • 识别了像退化和枢纽器官这样的新兴网络属性.
  • 证明了外围变化如何转化为影响大脑的系统信号.
  • 将复杂的行为与多系统性疾病联系起来.

结论:

  • 将大脑疾病重新定义为系统网络失调.
  • 突出了CONB网络通过免疫生物标志物的精密医学潜力.
  • 建议重新校准跨器官神经免疫网络,用于治疗策略和恢复平衡.
抽象的

No abstract available in PubMed .

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