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假阳性IMMY® 血清菌抗原侧流检测结果由于不适当使用定位缓冲区

Asmus Tukundane1,2, Wilber Bakka1, Mercy Amanige1

  • 1Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala P.O. Box 22418, Uganda.

Journal of fungi (Basel, Switzerland)
|February 26, 2026
PubMed

Insights

在加密球菌抗原 (CrAg) 侧向流量试验 (LFA) 中不正确使用定位稀释剂可能会导致错误阳性. 遵守制造商协议对于准确的Cryptococcus诊断和患者管理至关重要.

科学领域:

  • 临床诊断 临床诊断 临床诊断
  • 医学实验室科学 医学实验室科学
  • 传染病诊断 传染病诊断 传染病诊断

背景情况:

  • 在IMMY密码球菌抗原 (CrAg) 侧向流量测定 (LFA) 对于密码球菌检测至关重要.
  • 由于程序或试剂错误,可能会出现假阳性结果,影响诊断准确度.
  • 谨慎的测定操作是必要的,以防止误诊和不必要的治疗.

研究的目的:

  • 为了调查两个转诊患者的错误阳性Crag LFA结果的原因.
  • 为了确定导致诊断误解的具体程序错误.
  • 强调遵守制造商对Crag LFA的说明的重要性.

主要方法:

  • 根据制造商的协议,使用样品稀释剂重复 CrAg LFA 测试.
  • 半定量 CrAg LFA 测试和对照试验.
  • 连续稀释以评估不正确使用稀释剂的影响.

主要成果:

  • 用正确的样品稀释剂重复测试产生了负面结果.
  • 不一致使用定位稀释剂而不是样品稀释剂可重复生成的阳性结果.
  • 假阳性持续到1:80稀释,当定位稀释剂被滥用时.

结论:

  • 不适当地使用定位稀释剂而不是样本稀释剂可能是错误阳性CrAg LFA结果的可能原因.
  • 这种错误可能源于滴定稀释剂中缺乏阻断剂,该剂通常会中和异性恋抗体.
  • 严格遵守程序指南对于准确的诊断测试和有效的患者管理至关重要.
抽象的

No abstract available in PubMed .

关键词:
这是一种加密球菌抗原.一个错误的阳性假阳性.异性型抗体的异性型抗体.侧向流量检测试验样品稀释剂的稀释剂是什么标位稀释剂的调度稀释剂

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