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Updated: Mar 6, 2026

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整个生理学谱的皮质醇测定:与LC-MS/MS相比,访问免疫测定

Andrew J Newman1, Sanan Mahrokhian1, Isabelle Hanna1

  • 1Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Metabolism, Mass General Brigham, Harvard Medical School, Boston MA, USA.

European journal of endocrinology
|March 5, 2026
PubMed

Insights

这项研究表明,Access皮质醇免疫试验与黄金标准的液体染色学-并联质谱法 (LC-MS/MS) 密切相关,用于测量广泛的生理范围内的血清皮质醇水平.

科学领域:

  • 内分泌学 在内分泌学.
  • 临床化学 临床化学
  • 测试开发 测试开发

背景情况:

  • 皮质醇免疫测试被广泛用于上腺功能测试.
  • 之前的研究还没有全面验证针对LC-MS/MS的免疫检测性能,在皮质醇生产的全谱范围内.

研究的目的:

  • 为了比较Access皮质醇免疫试验与LC-MS/MS对血清皮质醇测量的性能.
  • 为了评估早晨免疫测试的准确性,德克萨梅他后抑制和后可辛热素刺激条件.

主要方法:

  • 一项涉及97名没有上腺疾病的成年人的横截面研究.
  • 在三个时间点使用Access Cortisol免疫测试和LC-MS/MS测量血清皮质醇.
  • 分析包括使用常见临床切线的相关性和一致性评估.

主要成果:

  • 访问皮质醇免疫试验显示,在整个生理学谱中与LC-MS/MS有很好的相关性.
  • 在较低的皮质醇水平 (德克萨米他后抑制) 中,达成一致性更接近于在较高水平 (后可辛热素刺激) 中.
  • 使用所有条件的标准解释截止值观察到高一致性 (科恩 κ > 0.89).

结论:

  • 访问皮质醇免疫测试提供可靠的皮质醇测量,与LC-MS/MS可比.
  • 临床医生可以自信地使用这种免疫测试来评估不同皮质醇水平的上腺功能.
抽象的

No abstract available in PubMed .

关键词:
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