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心脏托罗宁I的升高与心肌炎有关. 实验和临床相关的相关性

S C Smith1, J H Ladenson, J W Mason

  • 1Washington University School of Medicine, Department of Medicine, St Louis, Mo, USA.

Circulation
|January 7, 1997
PubMed

Insights

心脏素I (cTnI) 在诊断心肌炎方面表现有前途,为活检提供了一个不那么侵入性的替代方案. 升高的cTnI水平,特别是在心力衰竭的早期,可能有助于及时诊断和治疗这种情况.

科学领域:

  • 心脏病学 心脏病学
  • 免疫学 免疫学 免疫学
  • 生物标志物发现发现

背景情况:

  • 内心肌瘤活检是心肌炎诊断的标准,但具有侵入性和低产率.
  • 组织学诊断依赖于确定肌细胞损伤.
  • 心脏素I (cTnI) 是心脏肌细胞损伤的敏感和特定的血清标记物.

研究的目的:

  • 评估血清心脏素I (cTnI) 测量在诊断心肌炎中的有用性.
  • 将cTnI的诊断性能与肌酸酶-MB (CK-MB) 的诊断性能进行比较.

主要方法:

  • 在患有自身免疫性心肌炎的小鼠中测量了cTnI水平.
  • 测量了cTnI和CK-MB水平的患者和没有活检证明的心肌炎.
  • 评估了cTnI水平与心力衰竭症状持续时间的相关性.

主要成果:

  • 在 24/26 患有心肌炎的小鼠中,cTnI 升高.
  • 在患者中,cTnI在34%的心肌炎患者中升高,而在没有心肌炎患者中升高11% (P=.01).
  • CK-MB仅在5.7%的心肌炎患者中升高,而在没有心肌炎的患者中为0% (P=.27).
  • 在心肌炎患者中,cTnI的升高比CK-MB更频繁 (P=.001).
  • 升高的cTnI与持续时间≤1个月的心力衰竭症状相关 (P=.02).

结论:

  • 血清cTnI在检测肌细胞损伤时优于CK-MB.
  • 升高的cTnI水平在心力衰竭症状的第一个月更为常见,这表明早期诊断窗口.
抽象的

No abstract available in PubMed .

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