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Los antígenos HLA y la respuesta a corticosteroides
Science (New York, N.Y.)
|December 24, 1976
Resumen
Los pacientes con glaucoma primario de ángulo abierto muestran tasas más altas de antígenos HLA específicos y una mayor sensibilidad a los glucocorticoides. Sus linfocitos requieren dosis más bajas de prednisolona para inhibir la transformación, lo que sugiere un vínculo entre la respuesta inmune y el glaucoma.
Área de la Ciencia:
- Inmunogenética La inmunogenética.
- Oftalmología Oftalmología.
Sus antecedentes:
- El glaucoma primario de ángulo abierto (POAG) está asociado con tipos específicos de antígeno leucocitario humano (HLA).
- Los pacientes con glaucoma exhiben respuestas alteradas a los glucocorticoides.
Objetivo del estudio:
- Para investigar la asociación entre los antígenos HLA y la respuesta a los glucocorticoides en pacientes con AGPO.
- Para determinar si el antígeno HLA-B12 influye en la sensibilidad de los linfocitos a la prednisolona en individuos oculares normotensos y glaucomatosos.
Principales métodos:
- Comparación de la prevalencia del antígeno HLA en pacientes con AGPO frente a individuos normales.
- Evaluación de la respuesta de transformación de los linfocitos a la fitohemaglutinina.
- Cuantificación de las concentraciones de prednisolona requeridas para inhibir la transformación de los linfocitos.
Principales resultados:
- Aumento de la prevalencia de los antígenos HLA-B12 y B7 en pacientes con AGPO.
- Los linfocitos de individuos con el antígeno HLA-B12 (tanto el normotensivo ocular como el glaucomatoso) mostraron concentraciones significativamente más bajas de prednisolona necesarias para inhibir la transformación inducida por la fitohemaglutinina (P < .02).
Conclusiones:
- El antígeno HLA-B12 está relacionado con un aumento de la respuesta a los glucocorticoides en los linfocitos.
- Esta mayor sensibilidad puede desempeñar un papel en la patogénesis o progresión del glaucoma primario de ángulo abierto.
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