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Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
Aumento de la sensibilidad a la insulina y resistencia a la obesidad en ratones que carecen del gen de la proteína
M Elchebly1, P Payette, E Michaliszyn
1Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6.
Science (New York, N.Y.)
|March 5, 1999
Resumen
La eliminación de la proteína tirosina fosfatasa-1B (PTP-1B) mejora la sensibilidad a la insulina y el metabolismo de la glucosa en ratones. La deficiencia de PTP-1B también previene la obesidad inducida por la dieta y la resistencia a la insulina.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Investigación Metabólica de Investigación.
Sus antecedentes:
- La proteína tirosina fosfatasa-1B (PTP-1B) también regula negativamente la señalización de la insulina.
- Investigar el papel de PTP-1B es crucial para comprender los trastornos metabólicos.
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