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Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
Published on: July 18, 2016
La corriente externa transitoria, Ito1, se altera en la memoria cardíaca
1Departments of Physiology, State University of New York at Stony Brook, Stony Brook, NY, USA.
Circulation
|April 13, 1999
Resumen
La memoria cardíaca a largo plazo (LTM) en perros altera la morfología de las ondas T y los potenciales de acción. Los cambios en la corriente externa transitoria (Ito) están relacionados con estos efectos LTM.
Área de la Ciencia:
- Cardiología Cardiología.
- Electrofisiología y electrofisiología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- La memoria cardíaca es un fenómeno en el que la morfología alterada de la onda T persiste después de ritmos cardíacos anormales.
- Comprender los mecanismos celulares que subyacen a la memoria cardíaca es crucial para el diagnóstico y tratamiento de enfermedades cardíacas.
Objetivo del estudio:
- Para investigar los cambios electrofisiológicos y moleculares asociados con la memoria cardíaca a largo plazo (LTM) en un modelo canino.
- Determinar el papel de la corriente de potasio transitoria hacia el exterior (Ito) en las alteraciones cardíacas inducidas por LTM.
Principales métodos:
- La memoria cardíaca a largo plazo (LTM) fue inducida en perros conscientes por el ritmo ventricular durante 3 semanas.
- Se registraron electrocardiogramas (ECG) y potenciales de acción epicárdico.
- Se utilizaron técnicas de pinza de parche de célula completa para estudiar la corriente externa transitoria (Ito) en los miocitos epicárdicos del ventrículo izquierdo.
- Se evaluaron los niveles de ARN mensajero (ARNm) para Kv4.3.
Principales resultados:
- La LTM indujo cambios significativos en la amplitud y el vector de las ondas T en los ECG.
- Los potenciales de acción epicárdica mostraron una pérdida de muesca y una duración prolongada en los miocitos LTM.
- La activación transitoria de corriente hacia afuera (Ito) mostró un cambio de voltaje positivo, una densidad reducida y una recuperación significativamente prolongada de la inactivación en los miocitos LTM.
- Se observaron niveles reducidos de Kv4.3 de ARNm en los miocitos LTM.
Conclusiones:
- Las alteraciones en la corriente externa transitoria (Ito) están estrechamente asociadas con el potencial de acción observado y los cambios de onda T en la memoria cardíaca a largo plazo.
- Estos cambios de Ito proporcionan una explicación parcial de las manifestaciones electrofisiológicas de LTM.
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