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Updated: Jul 19, 2026
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
Correguladores transcripcionales en el desarrollo
1Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA.
Science (New York, N.Y.)
|April 24, 1999
Resumen
Pequeños cambios en las moléculas de señalización extracelular dictan el destino celular a través de la regulación transcripcional. Las proteínas correguladoras integran patrones complejos de expresión génica, mediando la comunicación con la ARN polimerasa II.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología Molecular Biología Molecular
- Regulación genética Reglamento genético.
Sus antecedentes:
- Las moléculas de señalización extracelular influyen en las decisiones del destino celular durante el desarrollo.
- La regulación transcripcional es un mecanismo clave para establecer respuestas de umbral.
- Los complejos patrones de expresión génica dependen de factores de transcripción específicos de la secuencia que se unen a las regiones cis-reguladoras.
Objetivo del estudio:
- Discutir los mecanismos de integración de información reguladora compleja en la expresión génica.
- Para resaltar el papel de las proteínas correguladoras en la mediación de la transcripción.
- Explorar cómo los coactivadores y corepresores facilitan la comunicación entre las proteínas reguladoras y el complejo de transcripción.
Principales métodos:
- Revisión de la literatura existente sobre la regulación génica y la señalización del desarrollo.
- Análisis de la función de los factores de transcripción específicos de la secuencia.
- Examen del papel de las proteínas correguladoras, los coactivadores y los corepresores.
Principales resultados:
- Las proteínas correguladoras son reclutadas por factores de transcripción en el ADN.
- Estas proteínas integran diversas entradas regulatorias.
- Los coactivadores y los corepresores forman un puente de comunicación con el complejo de transcripción de la ARN polimerasa II.
Conclusiones:
- Las proteínas correguladoras son cruciales para interpretar las complejas redes reguladoras de genes.
- Comprender estas interacciones es clave para descifrar la especificación del destino celular.
- La interacción entre las proteínas reguladoras y la maquinaria de transcripción central gobierna patrones precisos de expresión génica.
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01:10Transcription
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
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Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
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02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
01:17Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
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02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
01:17Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...