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Hiperhomocisteinemia: un factor de riesgo de accidente cerebrovascular isquémico en niños
I M van Beynum1, J A Smeitink, M den Heijer
1University Hospital Nijmegen, The Netherlands.
Circulation
|April 27, 1999
Resumen
La hiperhomocisteinemia moderada, un factor de riesgo en adultos, también está relacionada con el accidente cerebrovascular isquémico en niños. Este estudio encontró una asociación significativa, destacando su importancia en la salud vascular pediátrica.
Área de la Ciencia:
- Neurología Pediátrica.
- La medicina vascular es una medicina vascular.
- La bioquímica es la bioquímica.
Sus antecedentes:
- La hiperhomocisteinemia moderada es un factor de riesgo conocido para la enfermedad vascular arterial y la trombosis venosa en adultos.
- El papel de la hiperhomocisteinemia en el ictus isquémico pediátrico sigue siendo menos entendido.
Objetivo del estudio:
- Investigar la asociación entre hiperhomocisteinemia moderada y accidente cerebrovascular isquémico en niños.
- Para determinar si los niveles elevados de homocisteína son un factor de riesgo de accidente cerebrovascular en la población pediátrica.
Principales métodos:
- Se realizó un estudio de caso-control en el que participaron 45 niños con accidente cerebrovascular isquémico y 234 controles.
- Se midieron los niveles de homocisteína total en plasma (tHcy).
- La hiperhomocisteinemia se definió como tHcy por encima del percentil 95 para los controles específicos de la edad.
Principales resultados:
- La hiperhomocisteinemia se identificó en el 18% de los pacientes pediátricos con ictus isquémico.
- Una proporción de probabilidades de 4.4 (IC del 95%, 1.7 a 11.6) indicó un riesgo significativamente mayor.
- Los niveles elevados de homocisteína se asociaron fuertemente con el accidente cerebrovascular isquémico en niños.
Conclusiones:
- La hiperhomocisteinemia moderada se confirma como un factor de riesgo para el accidente cerebrovascular isquémico en niños.
- Estos hallazgos subrayan la importancia del cribado de homocisteína en la evaluación pediátrica del accidente cerebrovascular.
- Investigaciones adicionales pueden explorar intervenciones terapéuticas dirigidas a los niveles de homocisteína en niños afectados.
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