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Deficiencia oculta de vitamina D en mujeres posmenopáusicas estadounidenses con fractura aguda de cadera
M S LeBoff1, L Kohlmeier, S Hurwitz
1Department of Internal Medicine, Brigham and Women's Hospital, Boston, Mass 02115, USA. msleboff@bics.bwh.harvard.edu
JAMA
|May 5, 1999
Resumen
Las mujeres posmenopáusicas con fracturas de cadera a menudo tienen bajos niveles de vitamina D y altos niveles de hormonas paratiroideas. Abordar la deficiencia de vitamina D puede ayudar a prevenir futuras fracturas y mejorar la curación.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Metabolismo óseo Metabolismo óseo.
- Medicina Geriátrica La medicina geriátrica es una especialidad de la medicina geriátrica.
Sus antecedentes:
- Los bajos niveles de vitamina D están implicados en las fracturas de cadera entre las mujeres.
- Existen datos limitados sobre el estado de la vitamina D en mujeres estadounidenses con fracturas agudas de cadera.
Objetivo del estudio:
- Para comparar los niveles de vitamina D y la hormona paratiroidea en mujeres posmenopáusicas con fracturas de cadera frente a las que se someten a un reemplazo articular electivo.
- Para evaluar el estado de la vitamina D en mujeres ingresadas con fracturas agudas de cadera.
Principales métodos:
- Una serie de casos comparativos incluyó a 98 mujeres posmenopáusicas (30 con fracturas de cadera, 68 con reemplazo articular electivo).
- Los criterios de exclusión incluyeron condiciones o medicamentos que afectan la densidad ósea.
- Las medidas primarias fueron los niveles de 25-hidroxivitamina D y la hormona paratiroidea.
Principales resultados:
- Las mujeres con fracturas de cadera tenían niveles significativamente más bajos de 25-hidroxivitamina D en comparación con los grupos de reemplazo articular electivo no osteoporótico y osteoporótico.
- Los niveles de hormona paratiroidea fueron significativamente más altos en las mujeres con fracturas de cadera en comparación con ambos grupos de control.
- El 50% de las mujeres con fracturas de cadera tenían niveles deficientes de vitamina D (< o = 30,0 nmol / L).
Conclusiones:
- Las mujeres posmenopáusicas con fracturas de cadera con frecuencia presentan una deficiencia de vitamina D no diagnosticada.
- La reposición de vitamina D y la supresión de la hormona paratiroidea pueden reducir el riesgo de fracturas futuras y ayudar a la curación.
- Una mayor conciencia de la adecuación de la vitamina D es crucial, especialmente en las latitudes septentrionales.
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