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Pruebas genéticas en familias con cáncer de colon no polipósito hereditario
C Lerman1, C Hughes, B J Trock
1Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007-4104, USA. Lermanc@gunet.georgetown.edu
JAMA
|May 11, 1999
Resumen
Solo el 43% de los miembros de la familia con cáncer de colon no polipósito hereditario (HNPCC) aceptaron las pruebas genéticas. La educación inferior y los síntomas de depresión, especialmente en las mujeres, fueron barreras para la utilización de la prueba genética HNPCC.
Área de la Ciencia:
- Genética La genética.
- Oncología Oncología.
- Salud Pública La salud pública.
Sus antecedentes:
- Las pruebas genéticas para el cáncer de colon hereditario no polipósito (HNPCC) están disponibles.
- Se desconocen las tasas de aceptación y las barreras de las pruebas genéticas HNPCC.
Objetivo del estudio:
- Investigar las tasas de utilización de las pruebas genéticas HNPCC.
- Identificar los predictores de la absorción de las pruebas genéticas HNPCC.
Principales métodos:
- Estudio de cohorte de 208 miembros adultos de 4 familias HNPCC.
- Entrevistas telefónicas de referencia, educación familiar y asesoramiento genético.
- Evaluación de la aceptación por parte del participante de los resultados de las pruebas HNPCC.
Principales resultados:
- El 43% de los miembros de la familia aceptaron las pruebas genéticas HNPCC.
- La educación superior y la participación previa en estudios genéticos predijeron la aceptación de la prueba.
- Los síntomas de depresión disminuyeron el uso de la prueba HNPCC, especialmente en las mujeres.
Conclusiones:
- Una pequeña proporción de los miembros de la familia HNPCC utilizan pruebas genéticas.
- Las barreras incluyen educación inferior y depresión, particularmente en las mujeres.
- Se necesita más investigación para diversas poblaciones y entornos.
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