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Iniciación del desarrollo del hígado de mamíferos desde el endodermo por factores de crecimiento de fibroblastos
1Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Box G-J363, Providence, RI 02912, USA.
Science (New York, N.Y.)
|June 18, 1999
Resumen
Los factores de crecimiento de los fibroblastos (FGF) son clave para el desarrollo del hígado. FGF1 y FGF2 inician la expresión génica hepática, mientras que FGF8 promueve el crecimiento hepático en el desarrollo embrionario.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología Molecular Biología Molecular
- La organogénesis es la organogénesis.
Sus antecedentes:
- Las señales moleculares que impulsan la inducción hepática embrionaria desde el endodermo intestinal de los mamíferos siguen sin identificarse.
- Se sabe que el mesodermo cardíaco, que expresa los factores de crecimiento de los fibroblastos (FGF), induce el desarrollo del hígado desde el endodermo anterior.
Objetivo del estudio:
- Para identificar las moléculas de señalización específicas responsables de la inducción hepática embrionaria.
- Aclarar los distintos roles de los diferentes FGF en el inicio de la hepatogénesis y el crecimiento hepático.
Principales métodos:
- Tratamiento del endoderma embrionario de intestino delantero de ratón aislado con FGFs específicos (FGF1, FGF2, FGF8).
- Análisis de programas de expresión génica relacionados con la hepatogénesis.
- Investigación de la expresión del receptor FGF en el endodermo.
- Utilizando FGFs e inhibidores específicos para estudiar las fases de desarrollo.
Principales resultados:
- FGF1 y FGF2, pero no FGF8, podrían reemplazar el mesodermo cardíaco en la inducción del programa de expresión génica del hígado.
- La respuesta hepatogénica fue específica del endodermo que expresa los receptores 1 y 4 del FGF.
- Se encontró que FGF8 contribuye al crecimiento morfogenético del endodermo hepático.
Conclusiones:
- Diferentes señales del FGF orquestan diferentes etapas del desarrollo del hígado de los mamíferos.
- FGF1 / FGF2 inicia la hepatogénesis temprana, mientras que FGF8 impulsa los procesos morfogenéticos posteriores.
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