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La administración a largo plazo de ácido ascórbico revierte la disfunción vasomotriz endotelial en pacientes con
1Evans Memorial Department of Medicine, Cardiology Section, and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Circulation
|June 29, 1999
Resumen
El tratamiento con ácido ascórbico (vitamina C) mejoró la función endotelial en pacientes con enfermedad arterial coronaria (EAC). La suplementación de vitamina C a largo plazo mantuvo estos beneficios, lo que sugiere un potencial papel terapéutico en el manejo de la CAD.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Ciencias de la Nutrición Ciencias de la Nutrición
- Biología Vascular Biología Vascular
Sus antecedentes:
- La pérdida de óxido nítrico (EDNO) derivado del endotelio está implicada en la patogénesis de la enfermedad de las arterias coronarias (CAD).
- El aumento del estrés oxidativo perjudica la función vasomotora endotelial en la aterosclerosis.
- El tratamiento a corto plazo con ácido ascórbico (vitamina C) ha demostrado ser prometedor para mejorar la función endotelial.
Objetivo del estudio:
- Investigar los efectos de la dosis única y el tratamiento a largo plazo con ácido ascórbico en la dilatación mediada por flujo dependiente de EDNO en pacientes con CAD.
- Evaluar el impacto sostenido del ácido ascórbico en la función endotelial en la enfermedad arterial coronaria establecida.
Principales métodos:
- Estudio aleatorizado, doble ciego, controlado con placebo que involucró a 46 pacientes con CAD.
- Ultrasonido vascular de alta resolución utilizado para medir la dilatación mediada por flujo (FMD) al inicio, 2 horas después de la dosis única y 30 días después del tratamiento a largo plazo.
- Se monitorean los niveles plasmáticos de ácido ascórbico para confirmar la adherencia y eficacia del tratamiento.
Principales resultados:
- La dosis única de ácido ascórbico mejoró significativamente la fiebre aftosa del 6,6% al 10,1%.
- Esta mejora se mantuvo después de 30 días de tratamiento a largo plazo (9,0%), mientras que el placebo no mostró cambios significativos.
- Las concentraciones plasmáticas de ácido ascórbico aumentaron significativamente tanto con la dosis única como con el tratamiento a largo plazo.
Conclusiones:
- El tratamiento a largo plazo con ácido ascórbico demuestra un efecto beneficioso sostenido en la acción de EDNO en pacientes con CAD.
- Dado que la disfunción endotelial contribuye a los eventos cardiovasculares, el ácido ascórbico puede ofrecer un beneficio terapéutico para los pacientes con enfermedad arterial coronaria.
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