Video Experimental Relacionado
Updated: Aug 4, 2026
14:29
Examination of Thymic Positive and Negative Selection by Flow Cytometry
Published on: October 8, 2012
Selección positiva de las células B autoreactivas naturales
K Hayakawa1, M Asano, S A Shinton
1Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. K_Hayakawa@fccc.edu
Science (New York, N.Y.)
|July 3, 1999
Resumen
La exposición al autoantígeno promueve el desarrollo de células B y la producción de autoanticuerpos en un nuevo modelo murino. Esto demuestra que las células B, al igual que las células T, pueden someterse a una selección positiva basada en la auto-reactividad.
Área de la Ciencia:
- Inmunología Inmunología.
- Biología celular Biología celular.
- La autoinmunidad es autoinmunidad.
Sus antecedentes:
- El desarrollo de los linfocitos está regulado por autoantígenos.
- La selección de células T implica una selección positiva y negativa basada en la auto-reactividad.
- El papel del autoantígeno en la selección de células B positivas sigue sin estar claro.
Objetivo del estudio:
- Investigar el papel del autoantígeno en el desarrollo de las células B.
- Para determinar si las células B pueden someterse a selección positiva.
Principales métodos:
- Desarrollo de un modelo murino con células B naturalmente autorreactivas.
- Especificidad diseñada para la glicoproteína Thy-1 (CD90).
- Análisis de la acumulación de células B y la secreción de autoanticuerpos.
Principales resultados:
- La presencia de autoantígeno promueve la acumulación de células B.
- Las células B autorreactivas secretan autoanticuerpos.
- El modelo demuestra la selección positiva de las células B.
Conclusiones:
- Las células B pueden ser seleccionadas positivamente, generadas y mantenidas por el autoantígeno.
- La autorreactividad puede impulsar el desarrollo y la función de las células B.
- Este hallazgo amplía la comprensión de los procesos de selección de linfocitos.
Videos de Conceptos Relacionados
01:23Negative Regulator Molecules
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
01:20Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
01:28Diversity of Antigen Receptors
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
01:22T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
01:24B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...