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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
Published on: December 14, 2015
Diferencias en las vías del eje izquierdo-derecho en ratones y pollitos: funciones de FGF8 y SHH
1Department of Anatomy and Program in Developmental Biology, School of Medicine, and Department of Pediatrics, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA.
Science (New York, N.Y.)
|July 20, 1999
Resumen
El Factor de Crecimiento de Fibroblastos 8 (FGF8) actúa como un determinante izquierdo en los embriones de ratón, mientras que Sonic Hedgehog previene la expresión génica del lado izquierdo a la derecha, lo que difiere de las funciones del embrión de pollo.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología Molecular Biología Molecular
- Genética La genética.
Sus antecedentes:
- La asimetría izquierda-derecha es crucial para la organogénesis.
- Estudios previos identificaron FGF8 como un determinante derecho y Sonic Hedgehog como un determinante izquierdo en embriones de pollo.
Objetivo del estudio:
- Para investigar los roles de Fgf8 y Sonic Hedgehog en la determinación del eje izquierdo-derecho en embriones de ratón.
- Para comparar las funciones de estos genes en ratones frente a pollitos.
Principales métodos:
- Análisis de la expresión génica en embriones de ratón.
- Estudios funcionales que involucran a Fgf8 y Sonic Hedgehog.
Principales resultados:
- Fgf8 y Sonic Hedgehog son esenciales para establecer el eje izquierda-derecha en ratones.
- FGF8 funciona como un determinante izquierdo en los embriones de ratón.
- Sonic Hedgehog actúa para restringir la expresión génica del determinante izquierdo al lado izquierdo.
Conclusiones:
- Las funciones de FGF8 y Sonic Hedgehog en la determinación del eje izquierda-derecha difieren entre los embriones de ratón y pollo.
- FGF8 es un determinante izquierdo en ratones, y Sonic Hedgehog juega un papel crucial en el mantenimiento de la asimetría.
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