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Non-invasive Assessment of Microvascular and Endothelial Function
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El alfa-tocoferol plasmático y la función vasodilatadora dependiente del endotelio coronario dependen del endotelio
1Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. skinlay@massmed.org
Circulation
|July 21, 1999
Resumen
Los niveles plasmáticos de alfa-tocoferol están relacionados con una mejor función endotelial coronaria en pacientes con aterosclerosis. Un mayor nivel de vitamina E puede preservar la vasomovilidad mediada por el óxido nítrico, lo que sugiere un papel terapéutico.
Área de la Ciencia:
- Investigaciones Cardiovasculares Investigación Cardiovascular Investigaciones Cardiovasculares
- Ciencias de la Nutrición Ciencias de la Nutrición
- La función endotelial es la función endotelial.
Sus antecedentes:
- La respuesta vasomotriz endotelial coronaria a la acetilcolina es a menudo anormal en la aterosclerosis.
- Esta respuesta es variable entre los pacientes.
- Se investigó la asociación entre el alfa-tocoferol y la vasomoción mediada por óxido nítrico.
Objetivo del estudio:
- Para probar la hipótesis de que la concentración plasmática de alfa-tocoferol preserva la vasomoción dependiente del endotelio mediada por el óxido nítrico.
- Explorar la relación entre los niveles de vitamina E y la función endotelial coronaria.
Principales métodos:
- Se estudiaron 21 pacientes (15 hombres, 6 mujeres) sometidos a angiografía coronaria sin suplementos vitamínicos.
- Se evaluó la vasomoción coronaria dependiente y independiente del endotelio a través de infusiones intracoronarias de acetilcolina y nitroglicerina.
- Respuestas vasomotoras correlacionadas con alfa-tocoferol en plasma y su concentración relativa a los lípidos totales.
Principales resultados:
- El alfa-tocoferol plasmático se correlacionó significativamente con la vasomoción inducida por la acetilcolina (r=0.49, P<0.05).
- No se encontró una correlación significativa entre la respuesta del alfa-tocoferol y la nitroglicerina (r=0,13, P>0,05).
- La asociación entre la respuesta al alfa-tocoferol y la respuesta a la acetilcolina se mantuvo significativa después de ajustar por factores de estrés oxidante (P<0,01).
Conclusiones:
- El alfa-tocoferol puede preservar la función vasomotriz endotelial en la aterosclerosis coronaria.
- El efecto beneficioso podría deberse principalmente a la acción del alfa-tocoferol dentro de la pared vascular.
- Se justifica una mayor investigación sobre la suplementación con alfa-tocoferol para la disfunción endotelial.
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