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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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Variante de la enfermedad de Creutzfeldt-Jakob.
1Department of Neurogenetics, Imperial College School of Medicine at St Mary's, London, UK. J.Collinge@ic.ac.uk
Lancet (London, England)
|August 10, 1999
Resumen
Los priones de la encefalopatía espongiforme bovina (BSE) han causado una nueva enfermedad priónica humana, variante de la enfermedad de Creutzfeldt-Jakob (vCJD). Los riesgos para la salud pública de la posible transmisión iatrogénica y la exposición no cuantificada requieren una investigación adicional.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Epidemiología La epidemiología.
- Enfermedades infecciosas Enfermedades infecciosas.
Sus antecedentes:
- La encefalopatía espongiforme bovina (BSE) se ha relacionado con una nueva enfermedad priónica humana, variante de la enfermedad de Creutzfeldt-Jakob (vCJD).
- Epidemias anteriores de enfermedad priónica sugieren que la exposición durante la fase preclínica de la epidemia de EEB puede haber causado casos tempranos de ECJ v.
- Se anticipa la evolución a largo plazo de la vCJD, con potencial para casos generalizados en el futuro.
Objetivo del estudio:
- Analizar la dinámica de transmisión y las implicaciones para la salud pública de los priones de la EEB en humanos.
- Para resaltar la necesidad urgente de herramientas de diagnóstico y estrategias de evaluación de riesgos para vCJD.
- Para abordar las preocupaciones sobre la posible transmisión iatrogénica y la transferencia de priones entre especies.
Principales métodos:
- Revisión de los períodos de incubación de las epidemias históricas de la enfermedad priónica humana.
- Análisis de las barreras de transmisión de las especies.
- Evaluación de las posibles vías de transmisión iatrogénicas (sangre, tejido, instrumentos quirúrgicos).
Principales resultados:
- Los casos tempranos de vCJD probablemente fueron el resultado de la exposición durante la fase preclínica de la epidemia de EEB.
- Se desconoce el número de individuos que incuban vCJD, lo que representa un desafío significativo para la salud pública.
- La resistencia de los priones a la esterilización plantea preocupaciones sobre la contaminación de los instrumentos quirúrgicos.
- La transmisión iatrogénica a través de la transfusión de sangre y la donación de tejidos es un riesgo potencial.
- Los métodos de diagnóstico actuales (biopsia de amígdalas) son limitados; se necesita un análisis de sangre específico para priones.
Conclusiones:
- La aparición de vCJD a partir de la EEB representa una amenaza significativa para la salud pública.
- Es fundamental realizar más investigaciones para cuantificar los riesgos de transmisión y desarrollar medidas efectivas de diagnóstico y prevención.
- Permanece la posibilidad de que los priones de la EEB infecten a otras especies y representen riesgos continuos para la salud humana.
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