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Regulación dependiente del desarrollo y la actividad de los receptores de kainato en las sinapsis talamocorticales
1MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, UK.
Nature
|August 17, 1999
Resumen
El desarrollo de las sinapsis cerebrales utiliza receptores de kainato junto con los receptores AMPA. Su función disminuye con la plasticidad dependiente de la experiencia, lo que sugiere una regulación dependiente de la actividad de los receptores de kainato durante el desarrollo.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La transmisión sináptica es la transmisión sináptica.
- Función del receptor Función del receptor
Sus antecedentes:
- La transmisión sináptica excitatoria rápida en el cerebro de los mamíferos se basa en los receptores ionotrópicos de glutamato, incluidos los subtipos AMPA, NMDA y kainato.
- Los receptores de kainato se expresan ampliamente en el sistema nervioso central, pero sus funciones precisas siguen sin caracterizarse en gran medida.
- Los recientes avances en las herramientas farmacológicas permiten una mejor distinción entre los receptores de AMPA y kainato, lo que facilita los estudios funcionales.
Objetivo del estudio:
- Investigar el papel y la regulación de los receptores de kainato en el desarrollo de las sinapsis talamocorticales.
- Para determinar si los receptores de kainato están presentes postsinápticamente junto con los receptores de AMPA.
- Explorar la regulación del desarrollo y la plasticidad de la función del receptor kainato.
Principales métodos:
- Registros electrofisiológicos en el desarrollo de las sinapsis talamocorticales.
- Manipulación farmacológica para diferenciar entre las contribuciones de los receptores de AMPA y kainato.
- Investigación durante períodos críticos de plasticidad dependiente de la experiencia y potenciación in vitro a largo plazo.
Principales resultados:
- El desarrollo de sinapsis talamocorticales expresa tanto el kainato postsináptico como los receptores AMPA, que no se colocan.
- La contribución de los receptores de kainato a la transmisión sináptica disminuye durante el período crítico para la plasticidad.
- Se observa una disminución similar en la función del receptor de kainato después de la inducción in vitro de potenciación a largo plazo.
Conclusiones:
- Los receptores de kainato están presentes en el desarrollo de las sinapsis talamocorticales y su contribución a la transmisión está regulada dinámicamente.
- Los mecanismos dependientes de la actividad regulan la expresión o función de los receptores de kainato durante los períodos críticos del desarrollo.
- Esto sugiere un papel para los receptores de kainato en la plasticidad sináptica y el desarrollo del cerebro.
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